Eleva Reaches Industrial Production Scale and Prepares for Clinical Development of Factor H
Eleva, a manufacturer of superior biologics, is scaling up its production capacity to 2500 l in state-of-the-art single-use reactors. This will produce sufficient quantities of factor H to cover all three clinical phases.
Eleva has ordered four more state-of-the-art, 500 l single-use reactors with improved LED technology from Sartorius Stedim Systems GmbH. The scale-up will enable Eleva to enter clinical development of factor H, a key component of a pathway of the immune system known as alternative complement pathway.
The complement system enhances (complements) the body’s ability to clear microbes and damaged cells from an organism. Factor H regulates the activation of that immune response and ensures the body’s own cells are protected. Insufficient regulation of the complement system leads to excessive inflammation and potential tissue damage.
Factor H is a complex protein that only Eleva’s moss-based platform has thus far been able to yield in highest – human-like – quality. Eleva has been able to demonstrate a significant reduction in tissue damage and inflammation in animal models when its recombinant factor H was supplemented.
About Eleva
Based in Freiburg, Germany, Eleva develops novel biological therapies with its pharmaceutical partners. The privately-held company leverages its unique moss-based production platform to produce supreme biologics like antibodies, replacement enzymes, or fusion toxins. Eleva has successfully developed drug candidates into clinical phases.
About the complement system and Factor H
The human immune defence is divided into two strands: the adaptive system with antibodies and the innate complement system. The complement system consists of a group of proteins that recognize viral and bacterial patterns, trigger inflammation, and break up the pathogens. Factor H ensures that the system only attacks foreign cells by binding to host cells and regulates the main inflammation component, C3a.
Genetically derived lack of factor H dials up the amount of C3a, leading to immoderate inflammation and consequently tissue damage. A surplus of factor H, on the other hand, reduces the amount of C3a. Complement-associated diseases comprise kidney diseases and dry AMD.
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eleva GmbH
Fabienne Zeitter
pr@elevabiologics.com
Phone: +49 761 470 99 0
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